Appointment Setting Script that "weeds Out Losers"?

In this thread, John Galt mentioned one of the keys to setting appointments is to have a "strong script that weeds out losers."

http://ift.tt/2thy5C1

In all seriousness, how does one go about weeding out losers when setting appointments? What are the sure indicators that a person isn't worth meeting with, and what are the specific questions you could ask to identify these people on the call?
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